In the past decade, a growing body of scientific evidence showed the critical role of senescent cells in driving aging and age-related diseases. In particular, we and others reported that targeted apoptosis of senescent cells restores tissue function in response to chemotoxicity and aging in animal models (Baar et al., Cell, 2017).

 

At Rubedo Life Sciences we are developing a novel approach based on small molecules to clear senescent cells from aged or pathological tissues, supporting tissue regeneration and restoring organ function. 

 

Our approach will result in novel pharmacological treatments that are non-toxic and selective for senescent cells.